In the building at Jägerstra&szlig 49/50, which still stands today, Bankhaus Mendelssohn & Co. had its headquarters from 1893 to 1938.

After their marriage in 1762, the famous enlightener and pioneer of the Haskalah, Moses Mendelssohn, and his wife Fromet Mendelssohn (née Guggenheim) moved into the house at the former Spandauer Straße 68 (corner of Karl-Liebknecht-Straße). Before them, other enlighteners such as M. Mendelssohn's friend Gotthold Ephraim Lessing had already lived there. Until his death in 1786, M. Mendelssohn, like many Berlin Jews, was not allowed to buy the house.

The Jewish cemetery was inaugurated on 26.06.1881 by Rabbi Willstätter from Karlsruhe. Present were high-ranking representatives of  Grand Ducal and municipal authorities, the Catholic and Protestant city pastor, as well as many residents of Rastatt.

On 19.10.1941, the official order was issued by the Nazi regime, starting from the Rastatt District Office, to close the cemetery. The letter also referred to a decree of the Minister of the Interior.

The Birnbaum family lived here. The National Socialists converted the house into a  "Judenhaus" in 1938.