The Jewish cemetery at Grindel is named after its Hamburg neighborhood Grindel, which is located in the district of Rotherbaum. The cemetery was  laid out as early as 1712 on the outskirts of the city and initially served as a burial place for the poor and servants. It was not until 1835 that the cemetery became the main cemetery of the High German Jewish Community and the Portuguese Community in Hamburg, located in the Grindelviertel.  Only a few years later in 1909 the last burial took place and due to full occupancy the cemetery was closed.

The cemetery was established in the middle of the 18th century. It was the central burial place for the Jewish communities in Alsfeld, Romrod, Leusel (here only individual families belonging to Angenrod), Ober-Gleen and Grebenau, until these communities partly established their own cemeteries. The entrance gate was rebuilt in 1897 due to a foundation. During the Nazi period the cemetery was reduced by more than half of its original area. Today the cemetery area still covers 14.39 ares. The oldest gravestone dates back to 1842.